Our collaborators at the Institut Curie, Paris and NCNP, Tokyo have shown that signalling through the non-receptor tyrosine kinase SRC is upregulated in Group 4 medulloblastoma and furthermore, that ...

Scientists at The Hospital for Sick Children (SickKids) have identified a key gene that could lead to next-generation treatments for medulloblastoma, the most common malignant brain tumor in children.

Background While p53 mutations occur early in Barrett’s oesophagus (BE) progression to oesophageal adenocarcinoma (EAC), their role in gastric cardia stem cells remains unclear. Objective This study ...

SickKids researchers identified the KCNB2 gene as a key driver of medulloblastoma tumor growth. Blocking KCNB2 disrupts potassium channels, causing tumor-propagating cells to swell and lose integrity.

The TP53 gene is a gene that is mutated in many cancers. It is the most common gene mutation found in cancer cells. A tumor-suppressor gene, TP53 codes for a protein that inhibits the development and ...

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Rhabdomyosarcoma is a soft-tissue sarcoma that occurs most frequently in pediatric patients and has poor survival rates in patients with recurrent or metastatic disease. There are two major sub-types ...

TP53-p.Arg175His可减少p53靶标的激活并干扰野生型p53的激活，抑制细胞凋亡，降低基因组稳定性，促进肿瘤发生。而TP53-p.Arg196Ter突变可明显影响DNA 的激活及转录结合。 目前已有针对TP53突变靶向药物的多项相关临床研究正在开展中，包括MK-1775、ALT-801等。MB目前主要 ...

Despite a growing wealth of available molecular data, the growth of tumors, invasion of tumors into healthy tissue, and response of tumors to therapies are still poorly understood. Although genetic ...