It results from errors in the segregation of chromosomes from the mother cell to the two daughter cells during mitosis, i.e., cell division, and leads to the activation of p53, a key protein that ...

A new research paper was published in Oncotarget, Volume 16, on February 18, 2025, titled "Robust p53 phenotypes and prospective downstream targets in telomerase-immortalized human cells.

During mitosis, the chromatin undergoes a dynamic reorganization important for faithful chromosome segregation. Here the authors show that the DEAD-box RNA helicase eIF4A1/2 regulates the ...

Figure 8: Regulation of ALDH3A1 and NECTIN4 by p53. Researchers Jessica J. Miciak, Lucy Petrova, Rhythm Sajwan, Aditya Pandya, Mikayla Deckard, Andrew J. Munoz, and Fred Bunz from the Sidney ...

These results unveil a novel role for Vif in kinetochore regulation that governs the spatial organization of chromosomes during mitosis. These prior studies have predominantly employed ...

Cellular reprogramming is an intrinsic evolutionary trait to constantly promote adaptations that confer survival advantage.

MANILA – The Philippine Economic Zone Authority (Peza) has approved P52.93 billion worth of investment pledges in the first two months of the year. PEZA reported Tuesday that its investment ...

2025年2月18日，一篇新的研究论文发表在Oncotarget，第16卷，题为“端粒酶永生人类细胞中强大的p53表型和潜在的下游靶标”。 2025年2月18日，《Oncotarget》杂志第16卷发表了一篇题为“端粒酶永生化人类细胞中稳健的p53表型及潜在下游靶点”的研究论文。来自西德尼 ...

Remarkably, mutant centrioles also have an expanded proximal region. During mitosis, these mutant centrioles further elongate before fragmenting and disintegrating. All four proteins physically ...