The nuclear pore complex protein RANBP2 has emerged as a critical factor in the development and progression of various solid malignancies.

神经母细胞瘤（NB）中野生型 p53 的细胞质隔离机制不明。研究人员探究 TSPYL5 在其中的作用，发现 TSPYL5 通过 G3BP1/RanBP2 促进 p53 sumoylation，增强其核输出，增加 NB 细胞恶性特征，为 NB 治疗提供新方向。 在儿童癌症的世界里，神经母细胞瘤（NB）是一个可怕的 ...

Dnmt3a R878H/+ cells have a global hypomethylation phenotype and growth advantage over wild type cells. Following γ-irradiation, Dnmt3a R878H/+ mice show accelerated development of thymic T-cell ...

本文聚焦天然产物在癌症治疗中靶向 p53 的研究。p53 作为肿瘤抑制蛋白（野生型 p53（wt-p53）），突变（mut p53）后会促进癌症发展。文中梳理了多种调节 p53 的天然产物，为癌症治疗研究提供了丰富思路，极具科研价值。 引言 天然产物在药物研发中意义重大 ...

Sustained reactivation of mutant p53 drives durable anti-tumor activity across models, including KRAS co-mutant tumors FMC-220 selectively stabilizes p53 Y220C at lower doses, overcoming key ...

The work shows that the AGO2 protein follows the tumor suppressor p53 into the nucleus, binding itself to genes that regulate the body's alarm signals and turning them off. The researchers also ...