USP28 and p53 protein itself. These proteins only interact during unusually longer mitosis (longer than 30 minutes). During this prolonged mitosis, more and more of the complex is formed.

The improper segregation of chromosomes during cell division leads to abnormalities that disrupt the proper functioning of the cell. Cells with an abnormal number of chromosomes consequently ...

p53 and RB are at the heart of the two main tumour-suppressor pathways that control cellular responses to potentially oncogenic stimuli. Each pathway consists of several upstream regulators and ...