Conclusion: Our results highlight the potential use of CM-272 to induce apoptosis in SK-N-SH cells through p21 upregulation and an increase in BAX levels. Furthermore, our findings suggest that ...

University of Wisconsin-Madison, Madison, WI.

自1979年被发现以来，p53蛋白已成为了研究最为广泛和深入的肿瘤抑制因子之一。作为转录因子，p53调控众多下游信号通路，诱导细胞周期停滞、细胞凋亡和衰老是其最“经典”的功能，也被认为是其清除受损细胞、防止癌细胞发生的主要手段。学术经纬相关阅读：人类 ...

Cyclin D1–CDK4/6 phosphorylates GTSE1 in cancer cells, preventing its degradation and sustaining high levels across the cell cycle, which enhances proliferation and correlates with poor prognosis.

DON处理能抑制p53的脱酰胺修饰，恢复p53的电荷状态，重新激活其下游靶基因（如p21、PUMA），诱导细胞周期停滞和凋亡。 进一步研究发现，CAD可直接 ...

The E6 and E7 proteins are implicated in the transformation of a normal cell to a cancerous one by respectively guiding the cell to evade apoptosis ... binds to p53, resulting in ubiquitination ...