Conclusion: Our results highlight the potential use of CM-272 to induce apoptosis in SK-N-SH cells through p21 upregulation and an increase in BAX levels. Furthermore, our findings suggest that ...

University of Wisconsin-Madison, Madison, WI.

Tang Center for Herbal Medicine Research and Department of Anesthesia & Critical Care, Pritzker School of Medicine, University of Chicago, Chicago IL 60637, USA Tang Center for Herbal Medicine ...

Background: Triple-negative breast cancer (TNBC) is an aggressive sub-type of breast cancer that is associated with higher rates of recurrent disease. Chemotherapy with an anthracycline is an integral ...

This study aimed to validate the prognostic relevance of combined alterations in cell cycle regulators RB1, p53, and p21 in a broad cohort of MIBC patients undergoing radical cystectomy (RC). We ...

自1979年被发现以来，p53蛋白已成为了研究最为广泛和深入的肿瘤抑制因子之一。作为转录因子，p53调控众多下游信号通路，诱导细胞周期停滞、细胞凋亡和衰老是其最“经典”的功能，也被认为是其清除受损细胞、防止癌细胞发生的主要手段。学术经纬相关阅读：人类 ...

Nat Rev Mol Cell Biol, 9, 729-40. [66] Marcotte, Lacelle, and Wang (2004) Senescent fibroblasts resist apoptosis by downregulating caspase-3. Mech Ageing Dev, 10-11, 777-83. [67] Jackson and ...

The presence of Δ133p53 or Δ160p53 significantly reduced the binding of FLp53 to the p21 promoter ... of apoptosis. H1299 cells were seeded in a 6-well plate and transfected with 2 μg of various ...

Cyclin D1–CDK4/6 phosphorylates GTSE1 in cancer cells, preventing its degradation and sustaining high levels across the cell cycle, which enhances proliferation and correlates with poor prognosis.