The nuclear pore complex protein RANBP2 has emerged as a critical factor in the development and progression of various solid malignancies.

The nuclear pore complex protein RANBP2 has emerged as a critical factor in the development and progression of various solid malignancies. As a SUMO ...

随着生活压力增大等因素影响，卵巢早衰（POI）发病率上升，严重影响女性生育及健康。研究人员探究原花青素（PACs）对女性生殖系统的作用，发现 PACs 能通过调节 Sirt1-p53-p21 信号通路促进雌性生殖干细胞（FGSCs）增殖，延缓 POI，为改善女性生殖健康提供新方向。

Manchester United have been given fresh hope in the battle to sign Sporting CP striker Viktor Gyokeres. The summer transfer window will open in just over a month from now - which means speculation ...

We are investigating the mechanisms by which cancer mutations deregulate the normal processes of cellular function and growth ...

Australian researchers have discovered that a single mutation in the DNA sequence for a methylation enzyme dysregulates key ...

Australian researchers have discovered that a single mutation in the DNA sequence for a methylation enzyme dysregulates key ...

Dnmt3a R878H/+ cells have a global hypomethylation phenotype and growth advantage over wild type cells. Following γ-irradiation, Dnmt3a R878H/+ mice show accelerated development of thymic T-cell ...

One of the pathways involved in sensing and repairing this DNA damage is the p53 tumor-suppressor pathway. "We found that the p53 tumor-suppressor signaling pathway is silenced in cells with ...

“Notably, unlike agents that cause reversible cell cycle arrest, FMC-220 activates cancer cell-death pathways and remains highly active in the presence of elevated MDM2 levels, a driver of resistance ...