Autophagy is a process by which cellular material is degraded by lysosomes or vacuoles and recycled. Several autophagy pathways operate within a cell, including macroautophagy, microautophagy and ...

These experiments identify the PKA holoenzyme, primarily composed of the RIα and Cα subunits and AKAP11, as a kinase complex prominently associated with autophagy. In agreement with previous reports, ...

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"Hepatocyte DPP9 and autophagy"部分发现了DPP9与自噬的关联。DPP9-KO小鼠肝脏中自噬标志物beclin1和LC3B蛋白增加，而p62减少。同时，肿瘤抑制蛋白p53水平升高，但细胞增殖标志物Ki67无变化。这些结果提示DPP9可能通过调节自噬和p53来影响肝癌发生。 研究结论和讨论部分 ...

这篇综述深入探讨了自噬（Autophagy）在衰老与癌症中的双重作用机制 ... 抑癌作用??：清除突变蛋白（如p62堆积）、维持基因组稳定（通过同源重组修复DSB）和增强免疫监视（如促进抗原呈递）。??促癌作用??：在营养匮乏时，自噬回收氨基酸支持癌细胞存活 ...

Revenues, meanwhile, grew 15 percent to P62 billion from P54.1 billion. Megaworld will launch some P20 billion worth of projects this year, more than a third lower than last year’s P31.8 billion ...