In IBM, there are fibers with p62-positive coarse aggregates in the sarcoplasm. Endomysial infiltrating lymphocytes are positive for CD8. MHC-II staining on both the sarcolemma and the sarcoplasm of ...

Immunofluorescence staining, HE staining and Nissl staining were used to evaluate BV2 cell activation ... Elevated levels of SIRT1 enhanced the production of autophagy-associated proteins LC3-II/I and ...

Gaucher disease (GD) is an inherited disorder caused by recessive mutations in the GBA1 gene that encodes the lysosomal enzyme β-glucocerebrosidase (β-GC). β-GC hydrolyzes glucosylceramide (GluCer) ...

Rapamycin effects on mTOR signalling, autophagy, cartilage homeostasis and inflammation were analysed by immunohistochemistry and immunofluorescence staining. Results Rapamycin affected the mTOR ...

This paper presents the important finding that BNIP3/NIX, a mitophagy receptor, and its binding to ATG18 are required for mitophagy during muscle cell reorganization in Drosophila. Although the ...

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研究人员以食蟹猴（Macaca nemestrina）为模型，研究孕期母体感染流感病毒（Influenza A virus，FLUAV）和寨卡病毒（Zika virus，ZIKV）对母体和胎儿的影响。研究样本来自 5 个队列，包括怀孕的非人灵长类动物（nonhuman primate，NHP）和人类样本，涵盖胎儿 NHP 对照组、胎儿 NHP - 母体 ZIKV 感染组、胎儿 NHP - 母体 ...

We further found that neurons with accumulation of phospho-tau immunostaining contained rG4s, that rG4 structure can drive tau aggregation, and that rG4 staining density depended on APOE genotype in ...