为探究精神疾病中神经元细胞的病理机制，研究人员以精神分裂症（SZ）等精神病患者为对象，研究 p62 在其中的作用。结果发现患者嗅神经元细胞（ONCs）中 p62 蛋白上调，且其表达模式与健康人不同。该研究为理解精神病发病机制提供新视角。

Figure 1: Representative images of the induction of autophagy and the outcome of its suppression. Figure 2: The role of autophagy in development and differentiation in mammals.

Autophagy is a process by which cellular material is degraded by lysosomes or vacuoles and recycled. Several autophagy pathways operate within a cell, including macroautophagy, microautophagy and ...

为了攻克这一难题，中国医科大学附属第四医院和附属第一医院的研究人员展开了深入的研究。他们将目光聚焦在泛素特异性肽酶 10（Ubiquitin-specific peptidase 10，USP10）上，试图探索其在肺纤维化过程中的作用机制。研究结果令人振奋，他们发现 USP10 可能通过促进 Sirtuin 6（Sirt6）/AKT/mTOR 介导的自噬来减轻肺纤维化，这一发现为 IPF ...

In an ambitious move, Moderna has teamed up with OpenAI, the artificial intelligence company behind ChatGPT, to further integrate generative AI (GenAI) across its mRNA drug development and ...

在《Nature》期刊发表的这篇文章中，来自浙江大学的科研团队探讨了慢性压力如何通过调节神经元自噬影响抑郁症的发生。研究发现，急性压力会激活自噬，而慢性压力则抑制自噬，尤其是在大脑的外侧缰核（LHb）区域。不同类型的抗抑郁药物能够恢复LHb中的自噬功 ...

CureVac and partner GSK are, meanwhile, also developing an mRNA-based flu vaccine, but are a little further back in development, as their shot is in phase 1 testing.

本文研究揭开了mRNA疫苗效力背后的分子机制，强调了TENT5A在增强mRNA稳定性和免疫效力中的关键作用。 在抗击新冠疫情的全球战役中，mRNA疫苗以其 ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Skeletal muscle wasting results from numerous ...

每当提到mRNA，我们心中总是五味杂陈。 2023年9月，我们曾警示了当时mRNA疗法的巨大泡沫。虽然一个月后，mRNA新冠疫苗的发明者斩获诺贝尔奖 ...