为探究精神疾病中神经元细胞的病理机制，研究人员以精神分裂症（SZ）等精神病患者为对象，研究 p62 在其中的作用。结果发现患者嗅神经元细胞（ONCs）中 p62 蛋白上调，且其表达模式与健康人不同。该研究为理解精神病发病机制提供新视角。

ADPr condensates depend on and contain the selective autophagy receptor p62. ADPr condensates represent a subclass of p62 bodies ... Here, we have identified that IFNγ activates a transcription ...

Figure 1: Representative images of the induction of autophagy and the outcome of its suppression. Figure 2: The role of autophagy in development and differentiation in mammals.

Department of Ophthalmology, Tongji Hospital Affiliated with Tongji University, Shanghai 200065, People’s Republic of China ...

Abnormal autophagy is a key factor in the development of AS ... China); Antibodies against Beclin1, LC3B, P62, CD31, VEGF, TNF-α, and IL-10 were purchased from Proteintech (Wuhan, China); Antibodies ...

为了攻克这一难题，中国医科大学附属第四医院和附属第一医院的研究人员展开了深入的研究。他们将目光聚焦在泛素特异性肽酶 10（Ubiquitin-specific peptidase 10，USP10）上，试图探索其在肺纤维化过程中的作用机制。研究结果令人振奋，他们发现 USP10 可能通过促进 Sirtuin 6（Sirt6）/AKT/mTOR 介导的自噬来减轻肺纤维化，这一发现为 IPF ...

However, mRNA itself is an exceptionally unstable molecule. This does not affect the safety of the therapy but limits its effectiveness—for example, by shortening the duration of action.