编辑推荐：针对肝细胞癌(HCC)增殖调控机制不明的科学问题，南昌大学团队揭示了NUB1通过负调控NEDD8-PCNA轴抑制肿瘤生长的全新机制。研究发现NUB1缺失通过上调NEDD8促进PCNA Lys 164 位点NEDDylation，拮抗K48-linked多聚泛素化从而稳定PCNA蛋白，而NEDDylation抑制剂TAS4464可 ...

DNA replication is the biological process by which an exact copy of a deoxyribonucleic acid (DNA) molecule is created and it is the basis for biological inheritance. Each of the two strands of the ...