Inhibitors that target key components of this pathway, including PI3K, AKT and mammalian target of rapamycin (mTOR), are being actively developed. Some of them have reached clinical trials in ...

研究人员探究反复着床失败（RIF）病因，发现 Wnt/β -catenin 和 PI3K-AKT-mTOR 通路异常，为 RIF 治疗提供新思路。 ### 反复着床失败：生育难题背后的分子秘密 在生育的奇妙旅程中，反复着床失败（Recurrent implantation failure，RIF）成为了许多夫妻难以跨越的障碍。

本研究针对肝细胞癌(HCC)中miRNA异常调控的临床难题，研究人员通过RT-qPCR、双荧光素酶报告基因等技术，揭示了miR-518b通过靶向 ...

Anaplastic thyroid cancer (ATC), a rare yet highly aggressive malignancy, continues to represent a major clinical challenge.

This figure illustrates the major signaling pathways and their intricate crosstalk in BC, focusing on the GPCR, RTKs, RAS/RAF/MEK1/2/ERK1/2, MAPK, HER2, PI3K/Akt/mTOR, Wnt/β-catenin, NF-κB ...

The authors discuss several major pathways involved in breast cancer, including PI3K/Akt/mTOR, RAS/RAF/MEK/ERK, HER2, Wnt/β-catenin, Notch, NF-κB, and the DNA damage response (DDR). These ...

Our laboratory is dedicated to understanding the consequences of activation of these pathways and to using this information to develop mechanism-based therapeutic strategies. The laboratory is ...

Signaling in the PI3K/AKT/mTOR pathway is often disrupted in cancers, including ovarian cancer, Herzog noted in his introduction. In particular, key downstream pathways are mediated by AKT.

A systematic review published in Discover Oncology explores the anticancer efficacy of medicinal plant extracts in treating Oral Squamous Cell Carcinoma (O | Plants And Animals ...