The PI3K/AKT/mTOR (PAM) signaling pathway is a classical pathway that is aberrantly activated in cancer cells and promotes the tumorigenesis, metastasis, resistance to castration therapy, ...

Guang’anmen Hospital, China Academy of Chinese Medicine Sciences, Beijing, China Pharmacological interventions targeting the phosphatidylinositol-3-kinase/protein kinase B/mammalian target of ...

Inhibitors that target key components of this pathway, including PI3K, AKT and mammalian target of rapamycin (mTOR), are being actively developed. Some of them have reached clinical trials in ...

This figure illustrates the major signaling pathways and their intricate crosstalk in BC, focusing on the GPCR, RTKs, RAS/RAF/MEK1/2/ERK1/2, MAPK, HER2, PI3K/Akt/mTOR, Wnt/β-catenin, NF-κB ...

Liver injury is an independent risk factor for multiple organ dysfunction and high mortality in patients with sepsis. However, the pathological mechanisms and therapeutic strategies for ...

The authors discuss several major pathways involved in breast cancer, including PI3K/Akt/mTOR, RAS/RAF/MEK/ERK, HER2, Wnt/β-catenin, Notch, NF-κB, and the DNA damage response (DDR). These ...

Emerging evidence suggests a role for PI3K/mTOR signalling in the pathology of organ fibrosis ... signalling is an important component in TGF-β 1 induced αSMA and collagen gene expression and that an ...

The biomarker analysis found patients with certain mutations in the PI3K/AKT/mTOR pathway and MAPK pathway may be resistant to Truqap.

PI3K, AKT, and mTOR inhibitors – The survival blockers The PI3K/AKT/mTOR pathway is a regulator of cancer cell growth and survival, making it a target of choice. Several drugs have already made a ...

Zhejiang Provincial Key Lab for Chemical and Biological Processing Technology of Farm Product, School of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou ...