TCM contains numerous active compounds that can exert synergistic effects, intervening at multiple targets and regulating both upstream and downstream molecules of the PI3K/AKT pathway. In the future, ...

mammalian target of rapamycin complex 1/2; PDK1, phosphoinositide-dependent kinase 1; PI3K, phosphoinositide 3-kinase; PIP2, phosphatidylinositol (4,5)-bisphosphate; PIP3, phosphatidylinositol (3 ...

Phagocytosis is a fundamental mechanism used by the body to resist pathogens and restore physiological homeostasis. Herein, to identify small molecules with anti-inflammatory properties via ...

TSC1, Tuberous Sclerosis Complex 1; PI3K, Phosphatidylinositide 3-kinase; AKT1, AKT serine/threonine kinase 1; GATOR1, GAP activity toward Rags 1; GDP, Guanosine diphosphate; PGC1α Peroxisome ...

A team led by Prof. Wuran Wei from West China Hospital of Sichuan University and Dr. Dechao Feng from the Division of Surgery and Interventional Science at University College London has systematically ...

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TEDC1 and TEDC2, functions in generating centriolar triplet microtubules, and that this is crucial for the proper formation of centriolar subdomains and the stability of centrioles throughout the cell ...

The PIK3CA gene, which encodes the p110α subunit of phosphoinositide 3-kinase (PI3K), is among the most frequently mutated oncogenes in cancer. These mutations drive tumor progression ...

为解决糖尿病伤口愈合困难的问题，解放军总医院的研究人员开展了关于 NETs 对糖尿病伤口愈合影响的研究。结果发现 NETs 经 PI3K/Rac1 通路影响巨噬细胞吞噬功能，阻碍伤口愈合。该研究为治疗提供新策略，值得科研读者一读。 在当今社会，随着生活水平的提高 ...