Itovebi, approved for some patients with breast cancer, is the first PI3K inhibitor to display a survival benefit, according ...

Dr. Kevin Kalinsky discusses the role of targeted therapy and clinical decision-making in managing estrogen-driven, ...

Cell migration is an evolutionarily conserved mechanism that plays a role in normal and pathogenic processes, including embryogenesis, immunity, angiogenesis, wound healing, and cancer metastases.

Background: Pancreatic cancer is one of most aggressive malignancies with a dismal prognosis. Activation of PI3K/AKT signaling is instrumental in pancreatic cancer tumorigenesis. The aims of this ...

Clinical-stage BridgeBio Oncology Therapeutics, whose financial backers include Cormorant Asset Management, is going public by merging with a Cormorant-sponsored SPAC.

March 12, 2025 • To be a Palestinian-American writer right now can lead to a lot of expectation to focus on identity and devastation, but in her debut novel, Too Soon, Betty Shamieh shares the ...

为解决糖尿病伤口愈合困难的问题，解放军总医院的研究人员开展了关于 NETs 对糖尿病伤口愈合影响的研究。结果发现 NETs 经 PI3K/Rac1 通路影响巨噬细胞吞噬功能，阻碍伤口愈合。该研究为治疗提供新策略，值得科研读者一读。 在当今社会，随着生活水平的提高 ...

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Plectin drives hepatocellular carcinoma progression and metastasis through cytoskeletal reorganization and oncogenic signaling, making it a promising therapeutic target for overcoming therapy ...