Induction of collagen crosslinking stiffened the ECM, promoted focal adhesions, enhanced PI3 kinase (PI3K) activity, and induced the invasion of an oncogene-initiated epithelium. Inhibition of ...

Verastem Oncology , a biopharmaceutical company committed to advancing new medicines for patients with RAS/MAPK pathway-driven cancers, announced today multiple oral and poster presentations at the ...

This study explores the key molecular mechanisms involved, including dysregulation of calcium ions, altered connexin expression, and activation of signaling pathways such as TGF-β, PI3K/AKT, MAPK, ...

A substantial and persuasive body of data now exists that supports the view that integrin alpha V beta 3 plays a critical part in activated macrophage dependent inflammation, osteoclast development, ...

Targeting KRAS downstream effector molecules (PI3K, BRAF, mTOR, MEK, etc.), especially the combined use of downstream effector molecule inhibitors, shows promising prospects. Furthermore, the ...

Correspondence to Dr Jun Yu, Institute of Digestive Disease and The Department of Medicine and Therapeutics, Chinese University of Hong Kong, New Territories, Hong Kong; junyu{at}cuhk.edu.hk The gut ...

Figure. Overview of current and in development antiplatelet agents. COX-1 indicates cyclooxygenase-1; GPVI, glycoprotein VI; PAR1, protease-activated receptor-1; PDE, phosphodiesterase; PDI, protein ...