Interestingly, across the cell-line panel, lapatinib response was independent of PI3K mutation and PTEN status. “The immediate implications from this research are that other research groups can ...

During development, cells grow, expand, and migrate to generate tissues and organs in a highly controlled manner.

[8] The growth factor receptors HER2 and epidermal growth factor receptor (EGFR) activate PI3K, and they both figure prominently as oncogenes in numerous malignancies. Pten, a major tumor ...

A new review was published in , Volume 16, on March 13, 2025, titled "Signaling pathway dysregulation in breast cancer." ...

Innovations in therapeutic strategies, coupled with a deeper understanding of breast cancer biology, will be essential for advancing personalized ...

Compare that to Faslodex alone in patients with tumors harboring PI3K, AKT, or PTEN alterations (based on a hazard ratio of 0.50, p=<0.001; median PFS 7.3 versus 3.1 months). Price Action ...

Mutations in PIK3CA, AKT1, and alterations in PTEN occur frequently ... approval of Truqap “reinforces the important role of the PI3K/AKT pathway in HR-positive breast cancer and the critical ...