胆管癌（CCA）预后差，缺乏有效治疗手段。研究人员开展了异鼠李素（Iso）对 CCA 作用的研究。结果发现 Iso 可通过 PI3K/AKT 通路抑制 CCA 细胞增殖、侵袭和转移，AKT1 可能是其治疗 CCA 的靶点，为 CCA 治疗提供新方向。

为探究胃癌（GC）分子机制、寻找新治疗靶点，研究人员开展 eIF6 在 GC 中作用的研究。结果发现 eIF6 在 GC 组织中高表达，与不良预后相关，敲低 eIF6 可抑制肿瘤进展，其通过 PI3K/AKT 通路发挥作用，为 GC 治疗提供新方向。

The phosphoinositide 3-kinase (PI3K) pathway is a crucial signal transduction system linking the activation of receptor tyrosine kinases (RTKs), G protein-coupled receptors (GPCRs) and oncogenes ...

1Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan. 2Department of Obstetrics and Gynecology, The First Affiliated Hospital of Harbin Medical ...

Acute respiratory distress syndrome (ARDS) is a diffuse, acute, inflammatory lung disease characterized by a severe respiratory failure. Recognizing and promptly treating ARDS is critical to combat ...

Here, a degree is a pursuit of purpose where learning empowers you, well-being strengthens you and an experience-driven education leads to a meaningful career. Western is the place to become your best ...

Introduction: Arsenic (As) exposure is associated with lung toxicity and we aim to investigate the effects of arsenic exposure on lung fibrotic changes. Discussion: we demonstrated that continued ...