and cyclooxygenase-2 (COX-2), according to western blot analyses. BBR inhibited the expression of F-actin, a key protein in phagosome formation. Notably, BBR exerted its phagocytosis effects through ...

肿瘤治疗电场（TTFields）已用于治疗多种癌症，但部分患者疗效不佳。为探究原因，研究人员开展 TTFields 与 PI3K/AKT 通路关系的研究。结果发现 PI3K/AKT 通路参与癌细胞对 TTFields 的反应，抑制该通路可增敏。这为提升 TTFields 疗效提供新思路。

这进一步证实了 miR-374-5p 在体外能够抑制成骨细胞的分化和骨基质的沉积与矿化34。 miR-374-5p 与 PI3K/AKT 通路的相互作用：Western blot 分析表明，miR-374-5p 模拟物转染可显著增强 AKT 磷酸化水平，而抑制剂则降低其表达。通过共转染 miR-374-5p 模拟物和 PI3K/AKT 通路抑制 ...

然而，柚皮苷对宫颈癌的具体作用机制仍有待深入探讨。PI3K/Akt/mTOR通路是一条重要的细胞信号传导通路，涉及多种细胞刺激的激活，其功能在肿瘤的发生、进展和药物反应中起着至关重要的作用。通过靶向PI3K/Akt/mTOR通路的药物，已在多个研究中被证实可以抑制肿瘤的发展。因此，深入研究柚皮苷在宫颈癌细胞中对PI3K/Akt/mTOR通路的影响，不仅为宫颈癌的临床治疗提供了新的思路，也为开发新的 ...

(C, D) Quantitative reverse transcription-PCR and Western blot analyses of S1pr3 ... of M2 macrophage polarization via repression of the PI3K/Akt-Stat3 signaling pathway. The authors showed ...

The phosphoinositide 3-kinase (PI3K) pathway is a crucial signal transduction system linking the activation of receptor tyrosine kinases (RTKs), G protein-coupled receptors (GPCRs) and oncogenes ...

The results of the KEGG pathway enrichment analysis of YQQRG and renal fibrosis were combined, which showed that YQQRG’s renoprotective effects were strongly associated with the phosphatidylinositol 3 ...

The expression levels of BAX, BCL-2, AKT, PI3K, and PD-L1 were assessed by quantitative PCR and Western Blot. Results: IFN-γ- and sPD-1-overexpressing BMSCs exhibited high bioactivity and genetic ...

1Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan. 2Department of Obstetrics and Gynecology, The First Affiliated Hospital of Harbin Medical ...