为探究 IER5 的细胞功能及作用机制，研究人员开展了 IER5 对 PP2A/B55α 磷酸酶作用的研究。结果发现 IER5 是 PP2A/B55α 的核内抑制剂，明确了结合位点和抑制机制，还发现类似蛋白也存在相似作用，为调控 PP2A/B55α 提供理论基础。 IER5 是 AP1 调控的即刻早期反应（IER ...

The first group comprises the classic Ser/Thr phosphatases: the large phosphoprotein phosphatase (PPP) family (PP1, PP2A, PP2B, PP4, PP5, PP6 and PP7) and the protein phosphatase, Mg 2+ or Mn 2 ...

A groundbreaking study published in Research (2025, DOI: 10.34133/research.0545) has elucidated the molecular mechanisms by which protein phosphatase 2A (PP2A) regulates CD8+ T cell-mediated immune ...

Dual checkpoint inhibitors led to longer overall survival in patients with high-risk endometrial cancer who displayed ...

Caspase-9: a protein involved in initiating apoptosis, particularly in response to cellular damage or stress. PP2A: a protein phosphatase involved in regulating cell growth and apoptosis, and its ...