A groundbreaking study published in Research (2025, DOI: 10.34133/research.0545) has elucidated the molecular mechanisms by which protein phosphatase 2A (PP2A) regulates CD8+ T cell-mediated immune ...

Dual checkpoint inhibitors led to longer overall survival in patients with high-risk endometrial cancer who displayed ...

为探究 IER5 的细胞功能及作用机制，研究人员开展了 IER5 对 PP2A/B55α 磷酸酶作用的研究。结果发现 IER5 是 PP2A/B55α 的核内抑制剂，明确了结合位点和抑制机制，还发现类似蛋白也存在相似作用，为调控 PP2A/B55α 提供理论基础。 IER5 是 AP1 调控的即刻早期反应（IER ...

Recent studies have investigated the key roles exerted by ERAP1 and ERAP2 in maintaining cellular homeostasis, emphasizing their functions beyond traditional antigen processing and presentation. In ...

1 Guangdong Provincial People’s Hospital, Zhuhai Hospital (Jinwan Central Hospital of Zhuhai), Zhuhai, Guangdong, China 2 Affiliated Hospital of Qingdao University, Qingdao Cancer Institute, Qingdao ...

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