编辑推荐：针对肝细胞癌(HCC)增殖调控机制不明的科学问题，南昌大学团队揭示了NUB1通过负调控NEDD8-PCNA轴抑制肿瘤生长的全新机制。研究发现NUB1缺失通过上调NEDD8促进PCNA Lys 164 位点NEDDylation，拮抗K48-linked多聚泛素化从而稳定PCNA蛋白，而NEDDylation抑制剂TAS4464可 ...

Genetic markers are DNA sequences with known physical locations on chromosomes. They are points of variation that can be used to identify individuals or species, or may be used to associate an ...

In this study we evaluated the immunohistochemical expression of ferritinophagy-related proteins, namely Ferritin Heavy chain (FTH1) and NCOA4, and proliferating cell nuclear antigen (PCNA) in canine ...

Your doctor can use CEA as a “marker” to learn more about your cancer. The test can often help predict whether the cancer is growing or spreading to other parts of your body. It can also help ...

Dry erase markers are widely used in various environments including schools, offices, and households. They are typically applied to whiteboards, items made of glass, and specific laminated surfaces.

To follow RELA, it was labelled with a fluorescent marker and visualised using live ... MIA PaCa-2, PANC-1, Capan-1, SW-1990, and Panc05.04 were obtained from ATCC. RELA and PCNA were tagged ...

The DNA sliding clamp proliferating cell nuclear antigen (PCNA) is an essential co-factor for many eukaryotic DNA metabolic enzymes. PCNA is loaded around DNA by the ATP-dependent clamp loader ...