As the phagosome is the key organelle for the degradation of microbes and for the generation of bacterial peptides to be presented to lymphocytes, this issue is fundamental for understanding the ...

Elevated levels of the NO precursor, L-arginine (L-arg) also enhances NO production. NO may either act directly, or in combination with superoxide (∙O2–) to form peroxynitrite (ONOO∙), to kill ...

These include altering phagosome maturation, resisting oxidative stress, and forming protective niches within host cells. The host initially detects these pathogens through pattern recognition ...

Phagocytosis is a fundamental mechanism used by the body to resist pathogens and restore physiological homeostasis. Herein, to identify small molecules with anti-inflammatory properties via ...

Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, United States; Department of Microbiology, UMass Chan Medical School, United States; ...

在人体免疫系统的精锐部队中，巨噬细胞（macrophages）一直以"清道夫"的形象示人。但该发表于《自然》的突破性研究揭示，这些免疫细胞竟具备堪比"美食博主"的代谢绝技——它们不仅能吞噬细菌，还能将微生物残骸转化为维持自身运转的"营养套餐"。

在微观的生物世界里，病原菌与宿主细胞之间无时无刻不在进行着一场看不见硝烟的战争。当病原菌入侵宿主细胞后，它们会被包裹在一种名为吞噬体（phagosome）的膜状结构中。吞噬体就像细胞的 “武器库”，会逐渐成熟并与溶酶体融合，形成吞噬溶酶体 ...

This important study reveals that disrupting fatty acid metabolism in macrophages significantly restricts the growth of Mycobacterium tuberculosis, showing that impaired lipid processing triggers ...

当免疫细胞吞噬细菌后，那些"战败者"的残骸去了哪里？最新的研究揭晓了一个堪比科幻大片的真相：人体内的巨噬细胞（macrophages）不仅能消灭入侵 ...