Cyclin D1–CDK4/6 phosphorylates GTSE1 in cancer cells, preventing its degradation and sustaining high levels across the cell cycle, which enhances proliferation and correlates with poor prognosis.

Case Western Reserve University, Cleveland, OH.

Circle Pharma to Present Late-Breaking Data at AACR 2025 Demonstrating Mechanism of Action for Novel Cyclin A/B RxL Inhibitors Circle Pharma, a clinical-stage biopharmaceutical company focused on ...

在病理特征上，PTC 组织中 BCL-2 表达减弱，Cyclin D1 表达增强；淋巴瘤细胞则有各自独特的形态和免疫表型特征 。值得注意的是，在部分患者的同一淋巴结中，同时发现了 PTC 转移灶和淋巴瘤成分 。分子特征研究中，FISH 分析显示 FL 存在 BCL2/IGH 重排，MCL 存在 CCND1 ...

The poster will present new mechanistic insights into the anti-cancer activity of cyclin A/B RxL inhibitors, including their impact on DNA repair pathways and mitotic progression in E2F-high cancers.

The Tigers were the first team to shut out Georgia in almost 75 games to highlight Tuesday night's ACC action.

PARCHMENT, MI –– One of Parchment’s all-time greats has found a new basketball home. And it’s at the Division-I level. Jalen Kampen, the Panthers’ all-time leading scorer, flipped his ...

Here's how national seed races stack up and who helped/hurt their tourney cases in Week 10.

On Sunday, April 20th, during Matchday 5 of the National First Division Championship (CNS-D1) (Part 1) at Antoine Levelt Park in Saint-Marc, Baltimore SC became the first club officially qualified for ...

Researchers have developed a highly accurate blood test for Alzheimer’s diagnosis using the biomarker phospho-tau217, offering earlier detection and lower costs. A study involving over 1,700 ...