Cyclin D1–CDK4/6 phosphorylates GTSE1 in cancer cells, preventing its degradation and sustaining high levels across the cell cycle, which enhances proliferation and correlates with poor prognosis.

BACKGROUND/AIMS A checkpoint mechanism in late G1, whose regulation via loss of retinoblastoma protein (pRB) or p16, or overexpression of cyclin D1 or cyclin dependent kinase 4 (CDK4), has been ...

为探究口腔鳞状细胞癌（OSCC）诊疗新策略，研究人员开展关于 Cyclin D1 在 OSCC 中表达的研究。结果显示，OSCC 中 Cyclin D1 阳性，且其免疫反应性与细胞分化程度负相关。这表明 Cyclin D1 或可成为分子治疗靶点，改善 OSCC 预后。 口腔鳞状细胞癌（OSCC）在全球范围内 ...

Notably, Cyclin D1 protein plays a crucial role in miR-146b-induced BCa cell proliferation, as confirmed by Western blotting (p < 0.05), with each experiment performed in triplicate. Mechanistic ...

Case Western Reserve University, Cleveland, OH.

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This fundamental article significantly advances our understanding of FGF signalling, and in particular highlights the complex modifications affecting this pathway. The evidence for the authors' claims ...

Circle Pharma to Present Late-Breaking Data at AACR 2025 Demonstrating Mechanism of Action for Novel Cyclin A/B RxL Inhibitors Circle Pharma, a clinical-stage biopharmaceutical company focused on ...

在病理特征上，PTC 组织中 BCL-2 表达减弱，Cyclin D1 表达增强；淋巴瘤细胞则有各自独特的形态和免疫表型特征 。值得注意的是，在部分患者的同一淋巴结中，同时发现了 PTC 转移灶和淋巴瘤成分 。分子特征研究中，FISH 分析显示 FL 存在 BCL2/IGH 重排，MCL 存在 CCND1 ...

3 Graduate School of Biomedical Sciences at Icahn School of Medicine at Mount Sinai, New York, USA Objective Advanced hepatocellular carcinoma (HCC) is a lethal malignancy with limited treatment ...