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TTK:膀胱癌治疗新靶点 —— 调控线粒体自噬与凋亡的关键激酶
膀胱癌(BC)预后差且晚期治疗手段有限。研究人员开展 TTK 蛋白激酶在膀胱癌中作用的研究,发现 TTK 在 BC 组织和细胞系中上调,通过调节 ULK1磷酸化和前体 mRNA 剪接促进线粒体自噬,抑制细胞凋亡。该研究为 BC 治疗提供新方向。
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