We also assessed the changes in SOCS3 expression in primary cultured orbital fibroblasts upon stimulation with IL-1β and IGF-1 and investigated the effect of small interfering RNA (siRNA)-mediated ...

The maturation of human stem cell-derived cardiomyocytes (hSC-CMs) has been a major challenge to further expand the scope of their application. Over the past years, several strategies have been proven ...

2025年2月19日，中国科学院生物物理研究所范克龙和阎锡蕴团队在《Science Advances》期刊上发表题为"Bioengineered protein nanocarrier facilitating siRNA escape from lysosomes for targeted RNAi therapy in ...

在体外实验取得良好效果后，研究人员在体内进一步验证纳米颗粒的作用。药代动力学研究显示，纳米颗粒能够延长 siACSL3 在血液中的循环时间，使其在肿瘤组织中大量积累，有效沉默肿瘤组织中的 ACSL3 表达。在肝癌原位肿瘤小鼠模型和患者来源的异种移植（PDX）肿瘤小鼠模型中，纳米颗粒介导的 ACSL3 沉默显著抑制了肿瘤的生长和转移，延长了小鼠的生存期，且未引起明显的体内毒性。

Department of Clinical Pharmacy and Pharmacy Administration, Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, ...

PPARα is less expressed in the liver of patients with non-alcoholic fatty liver diseases (NAFLD). Several PPAR-targeting molecules, including dual agonists, are currently under investigation for NAFLD ...

siRNA能抑制特定致癌基因表达，展现出较好的抗肿瘤潜力。然而其临床应用面临多重障碍，如负电荷亲水性阻碍细胞摄取，溶酶体逃逸能力不足导致 ...

Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Texas A&M University, College Station, Texas 77843 , United States ...

Line thickness indicates the strength of data support. AAA indicates abdominal aortic aneurysm; and PPAR, peroxisome proliferator‐activated receptor. AAA indicates abdominal aortic aneurysm; BMI, body ...

This month's cover highlights the article Nup358 restricts ER-mitochondria connectivity by modulating mTORC2/Akt/GSK3β signalling by Joseph, Misha Kalarikkal and colleagues. The image shows a human ...