A new study of prion diseases, using a human cerebral organoid ... researchers from Papua New Guinea and the U.K. reveal the complex population structure and migration patterns ...

The ‘Molecular Devils’ That Cause the Most Fatal Diseases Ever Known CJD and similar brain diseases are caused by a misfolded version of the naturally occurring prion protein. When these rogue ...

POWELL — Prion disease experts are concerned about spillover of Chronic Wasting Disease into other species of wildlife, livestock and even humans from direct contact with or environmental ...

相较于正常顺序的人朊蛋白 (106 - 126) 片段，乱序后的多肽二级和三级结构发生显著改变。正常片段在溶液中可形成特定的 β - 折叠和无规卷曲结构 。而乱序后，由于氨基酸排列顺序改变，其二级结构元件的形成和分布改变，难以形成与正常片段相似的稳定结构 。

Dr. Yee's group published the first crystal structure of the human prion protein, whose conformational transformation to a pathogenic form is believed to be important in an intriguing family of ...

Modern studies of yeast and fungal prions confirm that protein conformations (that is, alterations of cellular components that are distinct from the DNA-based chromosomal genes) can control certain ...

Experts in prion diseases are worried that new strains of the disease could cause the disease to spread into other wildlife, livestock and possibly even humans. Jacob W. Frank/National Park ...

The Prusiner lab that reported a possible treatment regime for vCJD involving currently licensed drugs, has made another important advance in the battle against spongiform encephalopathies. In August ...

In TSEs the normal cellular prion protein (PrP C) is transformed into an infectious disease-associated isoform, PrP Sc — a potential target for immunotherapy. In the March 6 Nature, Anthony R. White ...

In the fight against diseases like Alzheimer’s and Parkinson’s, scientists have long struggled to predict how certain ...

Department of Health and Human Services (HHS) reorganization plans appear to have been revealed through a leaked Office of ...