Professor Christopher Denton discusses key aspects of the 2024 British Society for Rheumatology guideline on managing systemic sclerosis.

The initial report of a patient with visceral scleroderma without skin involvement was published in 1954, [1] and in 1962, the term "progressive systemic sclerosis sine scleroderma" was coined.

Because it is rare (the incidence rate for the systemic form is estimated to be 19 new cases per year per 1 million adults), many nurses and physicians have only read about scleroderma.

Anifrolumab is under clinical development by AstraZeneca and currently in Phase III for Systemic Sclerosis (Scleroderma). According to GlobalData, Phase III drugs for Systemic Sclerosis (Scleroderma) ...

Dupilumab is under clinical development by Regeneron Pharmaceuticals and currently in Phase II for Systemic Sclerosis (Scleroderma). According to GlobalData, Phase II drugs for Systemic Sclerosis ...

The aim was to update the 2009 European League against Rheumatism (EULAR) recommendations for the treatment of systemic sclerosis (SSc), with attention to new therapeutic ... RP and haematopoietic ...

1 Ophthalmology Department, Medical University of Bialystok, Bialystok, Poland 2 Department of Rheumatology and Internal Diseases, Medical University of Bialystok, Bialystok, Poland Purpose: Systemic ...

Objectives Although T cells have been implicated in the pathogenesis of systemic sclerosis (SSc), a comprehensive study of T-cell-mediated immune responses in the affected skin of patients with ...

The main affected organs in systemic sclerosis include the skin, lungs, kidneys, heart and blood vessels. Stem cells themselves or the exosomes secreted by them can act on the diseased tissues of ...

Progressive MS patients must show objective ... including myasthenia gravis, lupus, and systemic sclerosis. Phase 1/2 trials are already ongoing for those indications.

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