Monkeypox, caused by the monkeypox virus—a close cousin of smallpox—has spread rapidly worldwide. From 2022 to 2025, more ...

We observed correlations between IFNG expression in CD8+ T cells and CXCL9 expression in PanCK+ tumor cells, suggesting a potential mechanism of T cell recruitment and activation. Conclusions: This ...

为了开发更强效的猴痘病毒核心蛋白酶抑制剂，研究团队开展了猴痘病毒核心蛋白酶底物识别和催化机制的研究。基于核心蛋白酶天然底物P25K序列，利用醛基替换切割断裂的酰胺键设计了底物类似物I-G18，期望能够与催化中心Cys328共价结合，模拟催化中间体的结构特征。研究团队通过冷冻电镜技术，成功解析了Core Pro ...

4月22日，上海科技大学联合中国科学院上海药物研究所、清华大学、中国科学院武汉病毒研究所和重庆医科大学等多家单位在《自然》（Nature）上共同发表了题为“Substrate recognition and cleavage mechanism of ...

Norovirus GII.17 variants have overtaken GII.4 as the most prevalent strain and significantly increased norovirus outbreaks in the U.S. and European countries in 2024-2025Cocrystal Pharma’s pan-viral ...

Norovirus GII.17 variants have overtaken GII.4 as the most prevalent strain and significantly increased norovirus outbreaks in the U.S. and European countries in 2024-2025Cocrystal Pharma's pan-viral ...

4月22日，上海科技大学联合中国科学院上海药物研究所、清华大学、中国科学院武汉病毒研究所和重庆医科大学等多家单位在《自然》(Nature)上共同发表了题为“Substrate recognition and cleavage mechanism of the monkeypox protease, Core protease”的最新研究成果。

2025 年 4 月 22 日，上海科技大学杨海涛教授、上海科技大学/中国科学院上海药物所柳红研究员、清华大学饶子和院士、中国科学院生物安全大科学研究中心张磊砢研究员、重庆医科大学王炜副教授作为共同通讯作者，在国际顶尖学术期刊 Nature ...

This observation demonstrates how ions gain energy by bouncing off supercritical shocks, central to the Fermi acceleration mechanism. The research is published in Science Advances. Collisionless ...

How alterations in cell metabolism translate into specific developmental gene programs remains a major question. This study ...