Monkeypox, caused by the monkeypox virus—a close cousin of smallpox—has spread rapidly worldwide. From 2022 to 2025, more ...

Key Laboratory of Gastrointestinal Cancer (Fujian Medical University), Ministry of Education, Fujian Medical University, Fuzhou, 350122, China ...

This mechanism is important in a variety of normal and pathological processes, including growth factor signalling, cell adhesion, inflammation and cell survival. Elevated protease activity in the ...

We observed correlations between IFNG expression in CD8+ T cells and CXCL9 expression in PanCK+ tumor cells, suggesting a potential mechanism of T cell recruitment and activation. Conclusions: This ...

为了开发更强效的猴痘病毒核心蛋白酶抑制剂，研究团队开展了猴痘病毒核心蛋白酶底物识别和催化机制的研究。基于核心蛋白酶天然底物P25K序列，利用醛基替换切割断裂的酰胺键设计了底物类似物I-G18，期望能够与催化中心Cys328共价结合，模拟催化中间体的结构特征。研究团队通过冷冻电镜技术，成功解析了Core Pro ...

4月22日，上海科技大学联合中国科学院上海药物研究所、清华大学、中国科学院武汉病毒研究所和重庆医科大学等多家单位在《自然》（Nature）上共同发表了题为“Substrate recognition and cleavage mechanism of ...

Norovirus GII.17 variants have overtaken GII.4 as the most prevalent strain and significantly increased norovirus outbreaks in the U.S. and European countries in 2024-2025Cocrystal Pharma’s pan-viral ...

State Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, Hunan University, Changsha 410082, P ...

These proteases are ubiquitously represented across all domains of life and serve diverse functions including protein maturation, activation of signaling molecules and protein degradation. Categorized ...

Norovirus GII.17 variants have overtaken GII.4 as the most prevalent strain and significantly increased norovirus outbreaks in the U.S. and European countries in 2024-2025Cocrystal Pharma's pan-viral ...