The Human Domainome 1—the largest library of human protein variants—reveals the cause of certain genetic disorders, paving ...

The genetic code acts as life’s instruction manual, telling cells how to build proteins from DNA and RNA. Though it's a ...

Phosphoinositides recruit proteins to distinct intracellular membranes. Now, the Phox homology (PX) domain, an evolutionarily conserved protein domain whose function has so far been elusive ...

Using the CRISPR/Cas9 genome-editing system to mutate the gene regions encoding particular protein domains could result in a new and more efficient method to screen for druggable protein targets ...

Scientists at the Faculty of Medicine have now developed an innovative numbering system for the GAIN domain, a protein domain ...

Mammalian AMP-activated protein kinase (AMPK ... and γ-subunits with tandem domains that bind AMP or ATP. Recent crystal structures are providing insights into the interactions between these ...

People with inflammatory bowel disease (IBD) also have an increased risk of developing colorectal cancer. However, the exact ...

GAS2 is a cytoskeletal regulator that interacts with both F-actin and microtubules. Here, cryo-EM structures of GAS2 domains ...

In conclusion, Tim-3 was characterized as a novel immune checkpoint molecule with pathophysiological significance in respiratory oncology. Its stage-dependent expression dynamics and multimodal ...

Glyoxalase Domain-containing Protein 4 (GLOD4), the First Identified in a New Class of Enzymes Called Nitrases, Generates Nitrated ...