The Scientist2d
Unstable Protein Variants Linked to Many Human Diseases
The Human Domainome 1—the largest library of human protein variants—reveals the cause of certain genetic disorders, paving ...
The Brighterside of News on MSN1d
Existing models of genetic code evolution need revision, study finds
The genetic code acts as life’s instruction manual, telling cells how to build proteins from DNA and RNA. Though it's a ...
Hosted on MSN2mon
New numbering system standardizes protein domain comparison for better research
Scientists at the Faculty of Medicine have now developed an innovative numbering system for the GAIN domain, a protein domain common to all adhesion GPCRs. It should help to elucidate the role of ...
The Scientist9y
Targeting Protein Domains with CRISPR
Using the CRISPR/Cas9 genome-editing system to mutate the gene regions encoding particular protein domains could result in a new and more efficient method to screen for druggable protein targets ...
Nature1y
Membrane recognition by phospholipid-binding domains
At least 10 different types of globular protein domain are known that bind membrane phospholipids. Acidic phospholipids (especially phosphatidylserine and phosphoinositides) are the primary ...
Nature4y
GPCRs are membrane-bound proteins that have seven membrane-spanning domains connected by intracellular and extracellular domains.
In the inactive conformation, the a-subunit of the G protein binds to GDP and is bound to a beta-gamma complex (a). Upon receptor activation by its ligand, there is an exchange of GDP for GTP (b).
Nitrase Therapeutics Unveils Protein with Newly Characterized Enzymatic Function Involved in the Pathogenesis of Parkinson’s Disease
Glyoxalase Domain-containing Protein 4 (GLOD4), the First Identified in a New Class of Enzymes Called Nitrases, Generates Nitrated ...
Scientific Research Publishing6mon
Research Progress of T-Cell Immunoglobulin and Mucin Domain-Containing Protein-3 (Tim-3) in Respiratory Diseases ()
In conclusion, Tim-3 was characterized as a novel immune checkpoint molecule with pathophysiological significance in respiratory oncology. Its stage-dependent expression dynamics and multimodal ...