The cyclic AMP/protein kinase A (cAMP/PKA) pathway is one of the most common and versatile signal pathways in eukaryotic cells. A-kinase anchoring proteins (AKAPs) target PKA to specific substrates ...

Two-component system (TCS), which is comprised of a histidine kinase (HK) and a response regulator (RR), is a common mechanism whereby ... suggested that inhibitory activities of Velikova-13 and other ...

John Scott’s principal contribution was the discovery of AKAP signaling complexes that cluster the broad specificity signaling enzyme protein kinase A (PKA) with additional enzymes at defined ...

Late-stage pipeline products anticipated to reach the uveitis market during the forecast period will introduce new mechanisms ...

玉米作为全球广泛种植的重要粮食作物，其产量受到诸多环境因素的显著影响，其中干旱是最为关键的制约因素之一。相关研究表明，在关键生育期遭遇中度干旱，玉米产量可能会降低20%-40%，而重度干旱情况下，减产幅度甚至可能超过50%。干旱对玉米产量的负面影响不 ...

Arvinas is continuing its investigation of arv-102 in neurodegenerative diseases associated with lrrk2 and lysosome ...

BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) has become the most prevalent type of heart failure, but effective treatments are lacking. Cardiac lymphatics play a crucial role in ...