Phosphorylated sites in 196 kinases are related to other molecular functions such as localization and protein interactions. Over 8,000 phosphorylated sites, including all those in 517 kinases are ...

Dysregulation or mutations in kinases can result in numerous diseases. In fact, over 85% of the human kinome is involved in at least one disease or disorder, including cancer, cardiovascular disease, ...

To characterize the contributions of individual amino acids to the structure or function of a protein, researchers have adopted directed evolution approaches, which use iterated cycles of ...

Researchers at the Leibniz Institute on Aging—Fritz Lipmann Institute (FLI) in Jena have discovered a new function of the DNA repair protein ATR in regulating mitochondrial homeostasis.

We know each of the proteins that exist in our cells, but how they fit together to then carry out the function of a cell still remains largely unknown across cell types," said Leah Schaffer ...

Background Fibrolamellar carcinoma (FLC), a rare and fatal liver cancer lacking effective drug therapy, is driven by the DNAJ ...

A better understanding of lysosomal function may lead to new therapeutic ... the molecular mechanism by which the key autophagy protein ATG-9 promotes the repair of damaged lysosomes by regulating ...

In regenerative science, B7-33's potential to influence fibroblast activity and collagen turnover suggests possible implications for tissue repair and wound healing. Given that fibrosis is often a ...

Top-down proteomics: Intact proteins are ionized and analyzed directly, allowing for the study of proteoforms and ...

For example, receptor tyrosine kinases with Ig-like RTKs have been identified in protozoa (98 ... diversity of the IgSF in invertebrates and their pivotal roles in various biological processes. IgSF ...

Proteomics profiling of a pre-metastatic colorectal cancer cohort identifies four proteomics-based subtypes and highlights ...