The authors observed that frataxin knockout through Doxycycline administration in FRDAkd mice significantly reduced PC survival. Purkinje cell (PC) hypoexcitability could play a role in Friedreich ...

Currently, there appear to be three main cerebellar abnormalities observed in patients with ASD: diminished Purkinje cells, reduced cerebellar volume, and interrupted feedback pathways between the ...

Cerebellar ataxia, a hallmark of cerebellar degeneration (CBND), is driven by mitochondrial dysfunction in Purkinje cells. In this study, transplanting mitochondria into CBND mice improve ...

Mar. 11, 2025 — Researchers have identified genetic changes in blood stem cells from frequent blood donors that support the production of new, non-cancerous cells. Understanding the differences ...

Using an unbiased approach, this important study discovered a role of Ezh2 in the differentiation of granule neuron precursors, the cell of origin for Shh group of medulloblastoma. Furthermore, the ...

A new study from the University of Maryland School of Medicine has found a possible link between inflammation during ...

"Previously, research on cerebellar ataxias has primarily focused on the loss of cerebellar Purkinje cells. However, by the time cell loss occurs, therapeutic interventions are often ineffective ...

Microglial turnover correlates with the Purkinje neuron loss in 2HIT mice. Highly multiplexed imaging-mass-cytometry identifies a cell transition to TREM2(+) stress-associated microglia in the ...

Neuropathology in a presymptomatic case disclosed that Purkinje cells and hypoglossal neurons are affected. Conclusions SCA36 is rare with a worldwide distribution. It can be caused by a short GGCCTG ...