资讯

生物通3 天
新型噻唑酰胺类炎症小体(NLRP3)与细胞焦亡(pyroptosis)通路抑制剂的发现 ...
针对NLRP3炎症小体异常激活引发的细胞焦亡(pyroptosis)与多种炎症疾病，研究人员通过虚拟筛选与实验验证，发现新型噻唑酰胺化合物21能浓度依赖性抑制GSDMD切割、IL-1β释放及LDH渗出，其通过结合NLRP3活性位点并阻断NF-κB信号与GSDMD-NT寡聚化发挥广谱抑制作用 ...
生物通4 天
综述：NLRP3 炎性小体在自身免疫性疾病相关炎症中的作用机制
其次，应激产物等可增强激活过程，促进成熟炎性小体形成。NLRP3 寡聚化后招募 ASC，激活 procaspase-1，使其自切割，释放成熟的 IL-1β 和 IL-18，并促使 gasdermin D 裂解，引发细胞焦亡（pyroptosis）。适度的炎症反应有助于清除病原体和修复组织，但过度激活则可能 ...
The Manila Times1 天
GENFIT Reports Full-Year 2024 Financial Results and Provides Corporate Update
Cash and cash equivalents totaled €81.8 million as of December 31, 2024. In addition, completion in early 2025 of: (i) a non-dilutive royalty financing agreement for up to €185 million including a ...
GENFIT S.A.: GENFIT Reports Full-Year 2024 Financial Results and Provides Corporate Update
Cash and cash equivalents totaled €81.8 million as of December 31, 2024. In addition, completion in early 2025 of: (i) a non-dilutive royalty financing agreement for up to €185 million including a fir ...
Cancer Research5 天
Abstract 2997: Cell-based assay platforms for NLRP3 inflammasome drug discovery
Reaction Biology Corporation, Malvern, PA.
Cancer Research5 天
Abstract 2362: Bitter taste receptors detect oral dysbiosis and trigger oral cancer cell ...
Yonsei University College of Dentistry, Seoul, Republic of Korea.
腾讯网6 天
超越凋亡，操控细胞死亡的“多面手”如何带来抗癌新方法 |《自然 ...
自1979年被发现以来，p53蛋白已成为了研究最为广泛和深入的肿瘤抑制因子之一。作为转录因子，p53调控众多下游信号通路，诱导细胞周期停滞、细胞凋亡和衰老是其最“经典”的功能，也被认为是其清除受损细胞、防止癌细胞发生的主要手段。学术经纬相关阅读：人类 ...
globalcosmeticsnews2 天
Home Page [www.globalcosmeticsnews.com]
The Estee Lauder Companies has named Brian Franz to the new combined role of Chief Technology, Data & Analytics Officer, effective immediately. As the first combined CTDO, Franz will be responsible ...