This review synthesizes current knowledge on the METTL3-NLRP3 axis in pyroptosis, explores its therapeutic potential, and identifies critical research gaps for future investigation. This review ...

针对NLRP3炎症小体异常激活引发的细胞焦亡(pyroptosis)与多种炎症疾病，研究人员通过虚拟筛选与实验验证，发现新型噻唑酰胺化合物21能浓度依赖性抑制GSDMD切割、IL-1β释放及LDH渗出，其通过结合NLRP3活性位点并阻断NF-κB信号与GSDMD-NT寡聚化发挥广谱抑制作用 ...

Central to this process are the inflammatory cytokines interleukin-1β (IL-1β) and interleukin-18 (IL-18), which play crucial roles mediating intra-articular pyroptosis through the NOD-like receptor ...

Department of General Surgery, Tianjin Union Medical Center, Tianjin 300122, P. R. China These authors contributed equally to this work.

其次，应激产物等可增强激活过程，促进成熟炎性小体形成。NLRP3 寡聚化后招募 ASC，激活 procaspase-1，使其自切割，释放成熟的 IL-1β 和 IL-18，并促使 gasdermin D 裂解，引发细胞焦亡（pyroptosis）。适度的炎症反应有助于清除病原体和修复组织，但过度激活则可能 ...

Cash and cash equivalents totaled €81.8 million as of December 31, 2024. In addition, completion in early 2025 of: (i) a non-dilutive royalty financing agreement for up to €185 million including a ...

Cash and cash equivalents totaled €81.8 million as of December 31, 2024. In addition, completion in early 2025 of: (i) a non-dilutive royalty financing agreement for up to €185 million including a fir ...

Reaction Biology Corporation, Malvern, PA.

Yonsei University College of Dentistry, Seoul, Republic of Korea.

School of Basic Medical Sciences, Kunming Medical University, Kunming, Yunnan 650500, China ...