Recent structures of the Runx1–CBFβ heterodimer bound to DNA brings to six the number of characterized eukaryotic transcription factor families that use an immunoglobulin (Ig) fold to bind to DNA.

A new study has identified a critical mechanism that could lead to substantial advancements in the treatment of acute myeloid leukemia (AML).

In PVR and other diseases, the gene that RUNX1 regulates is overexpressed in the eye, causing scar tissue and abnormal blood vessels to grow. The investigators initially believed that targeting ...

Emeritus Professor of Experimental Haematology, Constanze Bonifer, wins prestigious award for advancing her field of research.