mTOR forms two complexes with different functions and regulatory mechanisms. mTORC1 is composed of three core components: mTOR, Raptor and mLST8. Raptor binds the TOR signaling motif to facilitate ...

Department of Neurosurgery, New York Medical College/Westchester Medical Center, Valhalla, NY.

Expert Rev Hematol. 2010;3(3):339-350. Everolimus is an oral agent targeting raptor mTOR (mTORC1). Its activity in 50 relapsed/refractory WM patients has recently been reported, with a promising ...

The Ford Raptor lineup is full of off-road capability added to standard Ford vehicles via pumped up engines and heavy-duty off-road hardware. Trucks like the Ranger Raptor and SUVs like the Bronco ...

Inhibitors that target key components of this pathway, including PI3K, AKT and mammalian target of rapamycin (mTOR), are being actively developed. Some of them have reached clinical trials in ...

F.N.B. Corp. (NYSE:FNB) is acquiring boutique investment banking firm Raptor Partners LLC. Raptor is based on Pittsburgh's North Side, in F.N.B.'s former headquarters building. The bank moved to ...

The RAG-RAPTOR-DEMO project simplifies the process of extracting and querying information from Complex PDF documents, including complex content such as tables, graphs, and images. Leveraging ...

F.N.B. Corporation FNB and its wholly-owned broker-dealer subsidiary are set to acquire Raptor Partners LLC, an independent investment (IB) banking firm. Details of the Raptor Buyout by FNB Raptor ...

CBR4 抑制由 FASN 介导的 mTOR 通路：分析敲低 CBR4 后肿瘤细胞的差异基因表达，发现 mTOR 信号通路显著改变。Western blot 结果显示，过表达 CBR4 抑制 mTOR 通路，敲低 CBR4 则激活该通路，抑制 FASN 可逆转敲低 CBR4 导致的 mTOR 通路激活，说明 CBR4 通过抑制 FASN 进而抑制 ...

The primary antibodies AMPK, p-AMPKa (Thr172), ULK1, p-ULK1 (Ser555), S6K, p-S6K (Thr389), mTOR, p-mTOR (Ser2448), p62, ATG5, Beclin1, RAPTOR, p-RAPTOR (Ser792) were purchased from Cell Signaling ...