LIG4 syndrome is an exceptionally rare disorder caused by a genetic mutation that prevents the body from repairing damaged ...

Witness the fascinating world of DNA replication brought to life through magnetic ball experiments. These magnetic games use a unique visual approach to demonstrate how the building blocks of life ...

[Editors' note: this paper was reviewed by Review Commons.] Cancer cells display high levels of oncogene-induced replication stress (RS) and rely on DNA damage checkpoint for viability. This feature ...

DNA replication is the biological process by which an exact copy of a deoxyribonucleic acid (DNA) molecule is created and it is the basis for biological inheritance. Each of the two strands of the ...

This study provides important new insights into the contributions of local DNA features to the complex molecular mechanisms and dynamics of copy number variation (CNV) formation during adaptive ...

A team has unearthed new findings about what happens during the minutes and hours after a cell divides, expanding our understanding of human biology -- and potentially leading to better medicines.

DNA repair and replication stress responses enable cancer cells to maintain optimal genome plasticity and also allow them to survive treatment with chemotherapeutic agents. Furthermore, cancers ...

DNA replication is happening continuously throughout the body, as many as trillions of times per day. Whenever a cell ...

Combining long-read DNA sequencing with a predictive artificial intelligence model has provided new insights into DNA replication.

Could viral infections play a role in Huntington's disease? Research suggests Apolipoprotein B mRNA editing catalytic ...

The study explores DNA damage and repair in neurons, which lack replication checkpoints due to their non-dividing nature. It reveals that DNA damage itself acts as a checkpoint, limiting genomic ...