Monoamine Oxidase Inhibitors (MAOi); tranylcypromine and pargyline, tranylcypromine derivative irreversible LSD1 inhibitors; GSK2879552, ORY-1001, ORY-2002, IMG7289, INCB059872, combination LSD1 and ...

investigational propargylamine that irreversibly and selectively inhibits monoamine oxidase type B (MAO-B). Rasagiline demonstrates complete and selective inhibition of MAO-B and is at least five ...

Numerous strategies have been used, including repurposing existing antivirals or drugs used in previous viral outbreaks. One such strategy is to repurpose FDA-approved kinase inhibitors that are ...

The teams found that TG2 acts as a regulator of intracellular monoamine neurotransmitters with an ability to not only add monoamines to histone H3 but also erase and exchange one monoamine ...

IMMULAB: A phase II trial of immunotherapy with pembrolizumab in combination with local ablation for patients with early stage hepatocellular carcinoma (HCC)—The IKF-IMMULAB trial. Trastuzumab ...

Sumatriptan and others are contraindicated in patients taking monoamine oxidase (MAO) inhibitors or within ... disorder manifesting in attacks of reversible focal neurological symptoms that ...

Hence, pathways that regulate macrophage phenotype are of strategic interest, with reprogramming strategies focusing on inhibitors of phosphoinositide 3-kinase-gamma (PI3Kγ) due to restricted immune ...

The express lanes were supposed to open in December, but more testing was required on the reversible gates, which led to a delay. Work on the express lanes is part of the second phase of the ...

CHICAGO (WLS) -- Drivers on the Kennedy Expressway can look forward to a quicker commute. Reversible express lanes are set to reopen by 5 a.m. Monday. The Illinois Department of Transportation has ...

The Kennedy Expressway’s reversible express lanes reopened Monday in time for morning rush hour after nearly a year of construction. The Illinois Department of Transportation said Sunday the ...