Ritonavir binds with CYP3A4 enzymes, which are responsible for metabolism, and gives nirmatrelvir a pharmacokinetic, or PK, boost. Unfortunately, ritonavir can also boost the lifetime of other ...

Inspra (eplerenone tablets; Pfizer, Inc., New York, NY) is an aldosterone blocker that works by binding at the mineralocorticoid receptor. It has some similarities to the potassium-sparing ...

利托那韦（ritonavir）成分会强烈抑制 CYP3A4 酶，从而导致他克莫司在血液中积累。该患者的毒性表现为多器官功能障碍，包括肌酐升高、胃肠道不适和手臂震颤。通过停用他克莫司和 Paxlovid，他克莫司水平下降了 47%。苯妥英（Phenytoin）是一种 CYP3A4 诱导剂 ...

This enzyme is called cytochrome p450 3A4 (CYP3A4). By slowing CYP3A4, these antifungals can cause Verzenio to build up in your body. This can increase your risk of Verzenio side effects.

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Revisiting the Drug Interaction Between Tamoxifen and SSRI Antidepressants. BMJ. 2016. 354:i5309. doi: 10.1136/bmj.i5309 Teft, WA. et al. CYP3A4 and seasonal variation in vitamin D status in addition ...

St. John’s wort may speed up the activity of an enzyme in your body called cytochrome P450 3A4 (CYP3A4). This enzyme helps break down Gleevec. By speeding up this enzyme, St. John’s wort can ...

Important pharmacological interactions: in combined use, drugs should have their doses readjusted: fluoxetine, serotoninergic, cimetidine increase methadone effects; carbamazepine, phenytoin, ...