Psoriasis is an autoimmune disease in which the skin becomes inflamed, producing red, flaky areas. It affects 1-2% of the population and is thought to be caused by misguided T cell attacks on the ...

Auto-inhibitory regulation of S100A8/S100A9-alarmin activity locally restricts sterile inflammation. J. Clin. Invest. 128; 1852-1866. Ulas T, Pirr S, Fehlhaber B, Bickes M, Loof TG, Vogl T, Mellinger ...

Figure 1. Schematic representation of the potential effects of S100A8/A9 in atherosclerosis. In neutrophils, S100A8 and S100A9 (S100A8/A9) promote expression of inflammatory mediators, phagocytosis, ...

The inflammatory bowel disease ulcerative colitis frequently progresses to colon cancer; however, the underlying mechanism is still unclear. S100a9 has been emerged as an important pro-inflammatory ...

The LXR agonist T091317 also suppressed responses, but not to the extent of myelin. We hypothesized that myelin would suppress cytokine production in the macrophage response to S100A9 and LPS. Methods ...

Recent transcriptomic studies indicated a connection between neuroinflammation, changes in neuroimmune responses, and the development of autism spectrum disorder (ASD). The microglial calcium-binding ...

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Senescent cells release a variety of cytokines, proteases, and growth factors collectively known as the senescence-associated secretory phenotype (SASP). Sustained SASP contributes to a pattern of ...

Apoptosis is characterized by profound morphological changes, but their physiological purpose is unknown. To characterize the role of apoptotic cell contraction, ROCK1 was rendered caspase ...

Importantly, glycolysis levels were also restrained after Bmal1 overexpression. What’s more, Bmal1 exerts a negative regulatory effect on glycolysis by interacting with S100A9 protein. Further studies ...

Johannes Roth (CRC 1009), Michael Schäfers (CRC 1450), Jan Rossaint (CRU 342) The long road to hybrid parametric imaging in PET/MRI: Methodological challenges and implications for imaging of ...