The IR bound IRS-1 is then itself tyrosine phosphorylated, creating a binding site for the SH2 domain of the adapter protein Grb2. The two SH3 domains of Grb2 bind proline rich motifs in the C ...

For example, tyrosine phosphorylated proteins have been shown to bind to Src homology 2 (SH2) and phosphotyrosine binding (PTB) domains 2, whereas serine/threonine phosphorylated proteins have ...