在视神经炎（ON）等视网膜神经退行性疾病中，视网膜神经节细胞（RGC）受损和视神经退化导致不可逆失明。研究人员针对此开展 SIRT1 疗法研究。结果发现 SIRT1 可平衡线粒体生物发生和自噬，保护 RGCs。这为视神经炎治疗提供新方向。 在眼科领域，视神经炎等 ...

为解决结直肠癌（CRC）转移机制不明及缺乏有效治疗靶点的问题，研究人员开展了 NR3C2-SIRT1 信号轴在 CRC 转移机制中作用的研究。结果发现该信号轴促进自噬、抑制上皮 - 间质转化（EMT），抑制 CRC 肺转移，为 CRC 治疗提供潜在靶点。 在全球范围内，癌症严重 ...

Rehabilitation and translocation programmes are increasingly becoming an important component of conservation action plans for threatened species. Translocation can help address gibbon conservation ...

Wogonin treatment markedly improved ejection fraction and attenuated myocardial fibrosis in PF mice. Mechanistic studies revealed that wogonin alleviated DNA damage and cardiomyocyte apoptosis by ...

Department of Microbiology & Cell Biology, Indian Institute of Science, Bangalore 560012, India ...

The Sirtuin family is a group of nicotinamide adenine dinucleotide (NAD+) -dependent histone deacetylases, including SIRT1 to SIRT7. They are involved in various biological ... β1-induced related ...

The translocation of these species is the key element of the project challenged by the plaintiffs in the lawsuit. Listed as threatened under the Endangered Species Act in 1998, bull trout ...

These guidelines are designed to be applicable to the full spectrum of conservation translocations. They are based on principle rather than example and are designed to provide guidance on the ...

The impact of inflammatory and bacterial challenges on CRP synthesis was tested using an adipocyte cell line. Bacterial translocation to mesenteric fat was studied in experimental models of colitis ...

The study conducted by Fang et al. offers significant and fundamental insights, notably enhancing our understanding of angiogenesis. While some of the claims are supported by convincing experimental ...