This interaction is maintained after IFN stimulation. RACK-1 is a scaffold protein with no enzymatic activity, which recruits specific signaling elements. RACK-1 directly interacts with IFNAR2, TYK2, ...

Positive correlations were found between STAT1 and IRF9 with Siglec-1 (CD169), an IFN signature marker expressed on the surface of CD14+ monocytes ... to a personalized approach for this specific ...

正常情况下，IFN-γ 与肿瘤细胞结合会引发信号转导和转录激活因子 1（STAT1）磷酸化，进而调节 C-X-C 基序趋化因子配体（CXCLs）、IFN 刺激基因（ISGs）和人类白细胞抗原（HLA）家族基因的表达，增强肿瘤抗原呈递，促进 CD8 + T 细胞的浸润和细胞毒性。然而 ...

PARP7 is a mono-ADP-ribosyl transferase (mono-ART) which has recently gained attention due to its emerging role as a negative ...

After incubation, 500μL of PBS containing fetal bovine serum was added to each tube, mixed, and centrifuged at 800 × g for 10 min. The supernatant was discarded, and 400μL PBS was added to resuspend ...

Patients: Patients with active IBD (n=42), disease specificity controls (n=8), and normal controls (n=12) were investigated. Methods: Expression and activation of STAT1 were assessed by western ...

(D) Localization of Ifn-λr1+ cells in the lungs of IAV-infected Wt mice at 7 dpi. Sections stained for Ifn-λr1 (red), Foxj1, uteroglobin or Sftpc (green) and DAPI (blue) are shown. (F-G) Calu-3 cells ...

We're expecting Motorola to debut the Edge 60 series – comprising the Edge 60, Edge 60 Pro, and Edge 60 Fusion – in the coming months, which is worth bearing in mind as you read through the ...