宁波大学附属第一医院的研究人员勇挑重担，开展了一项意义重大的研究。他们将目光聚焦于信号转导与转录激活因子（STAT）家族，这个家族在细胞周期、免疫反应和肿瘤发展过程中发挥着至关重要的作用，可其在结直肠癌中的功能和表达情况此前却并不明确。研究人员经过深入探索，发现 STAT3 和 STAT5B ...

All NSAIDs variably inhibit COX-1 and COX-2 and the mechanisms of inhibition fall into three broad categories, although there are exceptions. For example, nimesulide is a weak competitive ...

Our drug discovery model has identified two novel STAT3 SH2 domain inhibitors 323–1 and 323–2 (delavatine A stereoisomers) in a series of experiments. In silico computational modeling, drug affinity ...

Purpose: A summary of the basic science underlying the current controversies regarding cyclooxygenase-2 (COX-2)-selective nonsteroidal antiinflammatory drugs (NSAIDs), including data on their ...

The Last of Us Part 2 Remastered will release on April 3, 2025, for players on PC. As revealed during The Game Awards 2024, the Ellie-focused sequel heads to PC with a few upgrades beyond the ...

Who's ready to play Sara's new game? Get all the details here.

Cox Internet is well-known for its affordable and reliable service in the US. The brand provides internet services only in 19 states, but it has a solid reputation for providing a high-quality service ...

Nintendo Switch 2 is finally confirmed. After literal years of unverified rumors, dubious leaks and copious amounts of online speculation, Nintendo has lifted the lid on its next-generation ...

Way back in 2023, “Daredevil” star Charlie Cox disguised himself as Bluey so he could walk the floor without hassle at New York Comic Con. Of course, a few eagle-eyed fans did recognize him ...

Dodge & Cox’s January 2025 personnel update suggests ... the team recently increased the portfolio's duration to 6.2 years, in line with the index's, based on the belief that both rates and ...

Miscreants have attacked the Air Force Base near Cox's Bazar's Samiti Para, as per a notification from ISPR. The notice, signed by Ayesha Siddiqua, assistant director of ISPR, stated that the ...