This study presents a valuable finding on the direct cytotoxic effects of DuoHexaBody-CD37 in diffuse large B-cell lymphoma, mediated via SHP-1 activation and antibody clustering, independent of ...

Ltd. (1418.TO) Japan Year Ended February 28 GROUP 2025 2024 Revenue Y16.94 bln Y12.63 bln Operating Profit Y875.00 mln Y270.00 mln Pretax Profit Y875.00 mln Y245.00 mln Net Profit Y705.00 mln Y384 ...

本期推荐：肿瘤微环境(TME)中癌症相关成纤维细胞(CAFs)的激活机制一直是研究难点。中国研究团队发现CXCL12/STAT3信号轴是正常 ...

中文名称：目前未检索到统一规范的中文名称，暂可直译为 “信号转导及转录激活因子 3 适配体”（注：适配体是一类能与特定靶分子高亲和力、高特异性结合的寡核苷酸或短肽序列） 序列相关：由于 APT STAT3 通常指针对 STAT3 的适配体，适配体序列因不同研究 ...

In a subcutaneous tumor model, BZN markedly suppressed tumor growth in the mouse HNSCC cell line MOC1. Mechanistically, BZN may directly bind to the SH2 domain of STAT3, inhibit its dimerization, ...